“北+H”第一股来了？康乐卫士欲靠“押注”HPV疫苗突围

环球老虎财经2023-12-27

身披“国产HPV疫苗第一股”光环的康乐卫士，今年三月刚在北交所“流血”上市，近日又公告，将向H股发起冲刺。康乐卫士或有望成为“北+H”第一股。 12月26日，康乐卫士公告，公司计划发行境外上市外资股（H）股并申请在港交所上市。据了解，康乐卫士是今年6月北交所、港交所签署合作谅解备忘录以来，首家预备“北+H”两地上市的企业。或受此消息影响，截至12月26日收盘，康乐卫士收获“30CM”...

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Recreation guards want to break through by \"betting\" HPV vaccine","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"H":1},"content_text":"身披“国产HPV疫苗第一股”光环的康乐卫士，今年三月刚在北交所“流血”上市，近日又公告，将向H股发起冲刺。\n\n\n\n康乐卫士或有望成为“北+H”第一股。\n12月26日，康乐卫士公告，公司计划发行境外上市外资股（H）股并申请在港交所上市。\n据了解，康乐卫士是今年6月北交所、港交所签署合作谅解备忘录以来，首家预备“北+H”两地上市的企业。\n或受此消息影响，截至12月26日收盘，康乐卫士收获“30CM”涨停，12月27日，康乐卫士盘中涨超14%，随后回落，截至收盘，跌2.99%，报26.57元/股，目前市值74.65亿元。\n即便今日股价下跌，本周内康乐卫士的股价累计涨幅依然达40.81%，不过，目前公司股价依然处于破发状态。\n虽有着“国产HPV疫苗第一股”的名号，但实际上，康乐卫士的日子并不好过。今年三月，康乐卫士才刚刚“流血”登陆北交所，融资金额从最初期望的35亿降为了实际募资的3亿，同时，今年前三季度，公司净利润亏损达2.25亿元。\n此次筹划H股上市，或许是康乐卫士再次为公司“补血”的机会。不过，虽然目前国产HPV疫苗市场仍有空缺，但竞争者也在不断涌现，康乐卫士的HPV疫苗究竟能抢占多少市场份额、吸引多少投资者还未可知。\n\n\n\n康乐卫士或成“北+H”第一股\n康乐卫士此次将融资目光瞄准港交所。\n根据公告，康乐卫士此次H股上市募集资金将用于公司核心产品的临床试验及批准、多个临床前项目的研发、昆明产业化基地的生产前准备及生产工艺提升、完善商业化网络建设、国际临床及本土化生产、国际市场拓展、运营资金及其他一般公司用途等。\n据了解，今年6月底，北交所刚与港交所在北京签署合作备忘录，正式推出“北+H”两地上市安排。\n此次若成功在H股上市，康乐卫士将成为北交所“第一个吃螃蟹的人”。\n康乐卫士似乎一直以来都敢于“尝鲜”，其是北交所首家第四套标准上市企业，即预计市值不低于15亿元，最近两年研发投入合计不低于5000万元。\n值得一提的是，康乐卫士的上市之路可以说是一波三折。\n2022年3月，康乐卫士向北交所提交上市申报材料，当时计划融资金额为35亿元，发行底价为77.68 元/股。不过，该融资计划没有得到北交所的认可。\n2022年12月16日康乐卫士提交注册稿时，将融资金额降至23.8亿元，发行底价不变。2022年12月23日，康乐卫士成功过会。\n2022年12月26日，康乐卫士再次大幅度削减融资金额，将发行股份数从不超过4453万股暴降至不超过805万股，发行底价调低至45元/股，融资总额直接降至3.6亿元左右。2023 年2月28日，康乐卫士又突然宣布再次修改发行底价，从之前的45元/股暴降至9.1元/股。\n最终，在今年3月15日，康乐卫士以42元/股的发行价成功登陆北交所，发行数量为805万股，募资额为3.381亿，全额行使超额配售选择权后，募资总额为3.08亿元。\n融资金额从最初期望的35亿元降为了实际募资的3亿元，对康乐卫士来说，落差巨大。此次筹划H股上市或许也是康乐卫士再次获得资金支持的机会。\n\n\n\n亟需“补血”\n据了解，康乐卫士主要从事重组蛋白疫苗的研究、开发和产业化。不过，目前公司疫苗产品均处于研发阶段，尚无疫苗产品上市销售，也就无法为公司带来利润。\n康乐卫士也表示，公司主营业务收入来源于技术服务和销售科研用检测试剂，未能覆盖公司研发和日常经营需要，公司尚未盈利且存在累计未弥补亏损。\n数据显示，今年前三季度康乐卫士实现营收160.1万元，同比增长80.3%；净利润亏损2.25亿元，亏损幅度扩大6.76%。而2022年和2021年，康乐卫士净利润分别亏损2.93亿元，和3.80亿元。\n以此计算，2021年至今，公司累计亏损金额已达8.98亿元，北交所上市时融资获得的3亿元远不足以“填坑”。这样来看，上市还不到九个月，就又急于登陆H股融资“补血”，似乎也不难理解。\n连年亏损对应的是康乐卫士高企的研发费用，2021、2022及2023年前三季度，公司的研发费用分别为2.18亿元，2.37亿元和1.77亿元。\n此外，康乐卫士截止三季度的货币资金仅有2.53亿，对于一个年亏损超2亿的又未有足够营收的药企而言，其手上的现金可谓有点捉襟见肘。\n值得一提的是，虽然公司尚未盈利，也未有产品上市，但康乐卫士的股东席可以说是“卧虎藏龙”。\n财报数据显示，康乐卫士的前十大股东中，海南云锋基金中心（有限合伙）的合伙人包括浙江天猫技术有限公司、淘宝（中国）软件有限公司以及上市公司分众传媒旗下的上海分众鸿意信息技术有限公司；北京亦庄生物医药并购投资中心（有限合伙）股权穿透后有上市公司赛升药业以及北京国资的身影；云南滇中恒升投资发展有限公司、云南省滇中产业发展集团有限责任公司则都是出自云南国资旗下。\n\n\n\n国产HPV疫苗之战谁能胜出？\n在上市之初，康乐卫士就被称为“国产HPV疫苗第一股”，但这并不意味着康乐卫士可以“高枕无忧”。\n目前全球上市的HPV疫苗主要有三种，分别是二价、四价和九价。“价”表示疫苗可预防的病毒种类，二价疫苗覆盖预防HPV16和HPV18型病毒感染，全球70％的宫颈癌和宫颈癌癌前病变与HPV16、HPV18型病毒有关；四价疫苗覆盖预防6、11、16、18型HPV病毒；九价疫苗则在此基础上又多覆盖了五种亚型。\n据康乐卫士披露，公司目前共有10个重组人用疫苗在研项目，其中，三价HPV疫苗、九价HPV 疫苗（女性适应症）和九价HPV疫苗（男性适应症）均已进入Ⅲ期临床，十五价HPV疫苗已取得国家药监局的临床试验批准通知书。此外，呼吸道合胞病毒疫苗、多价诺如病毒疫苗、带状疱疹疫苗、多价手足口病疫苗和脊髓灰质炎疫苗等在研项目均处于临床前研究阶段。\n华安证券研报预测2030年HPV疫苗市场规模将增长至690亿元，2020-2030年的复合年增长率为17.7%。面对HPV疫苗的广阔蓝海，国内疫苗制造企业也都在加快研发脚步，希望快速抢滩。\n目前二价HPV疫苗已经实现国产化，万泰生物和沃森生物已有两款获批上市，康乐卫士似乎也无意参与二价HPV疫苗的竞争，而是针对性地推出了三价HPV疫苗，据统计，目前国内也仅有康乐卫士在研发重组三价HPV疫苗。\n不过，最炙手可热的还是九价HPV疫苗，并且目前仍未有国产九价HPV疫苗成功上市，智飞生物独家经销的默沙东九价HPV疫苗几乎“垄断”了国内市场，甚至曾出现“一针难求”的现象。\n市场对国产九价HPV疫苗也是翘首以盼，近日，另一家上市公司万泰生物的九价HPV疫苗Ⅲ期主临床试验V8期访视的现场工作完成，带动公司股价近9个工作日大涨超55%。\n除康乐卫士和万泰生物外，沃森生物、上海博唯生物科技有限公司、瑞科生物目前的九价疫苗研发也都正在进入或已进入到临床III期研发阶段。\n不过，据业内人士预测，国产九价HPV疫苗最快也要到2025年左右才能投入市场。未来，国产疫苗能否“打败”进口疫苗，究竟哪家企业能率先实现九价疫苗上市还需拭目以待。\n责任编辑 | 陈斌\n\n\n\n\n\n\n\n\n\n.data_color_scheme_dark{--weui-BTN-ACTIVE-MASK: rgba(255, 255, 255, .1)}.data_color_scheme_dark{--weui-BTN-DEFAULT-ACTIVE-BG: rgba(255, 255, 255, .126)}.data_color_scheme_dark{--weui-DIALOG-LINE-COLOR: rgba(255, 255, 255, .1)}.data_color_scheme_dark{--weui-BG-COLOR-ACTIVE: #373737}.data_color_scheme_dark{--weui-BG-6: rgba(255, 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